Description

Dehydro Aripiprazole-D8 is a deuterium-labeled analog of the antipsychotic drug aripiprazole, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) involved in drug metabolism, pharmacokinetic (PK) studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise quantification of aripiprazole and its metabolites in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track and measure drug concentration over time, enabling accurate PK parameter calculation.
• Bioanalytical Method Development and Validation: Serves as a stable, isotopically-labeled reference to correct for matrix effects and instrument variability.
• Clinical and Pre-clinical Research: Supports studies on the efficacy, safety, and therapeutic monitoring of aripiprazole.
• Forensic and Toxicology Testing: Aids in the accurate identification and quantification of aripiprazole in forensic casework.
• Pharmaceutical Quality Control: Can be employed in impurity profiling and stability-indicating assay methods for drug substance and product analysis.

Basic Information

Product Name	Dehydro Aripiprazole-D8
CAS No.	1215897-99-6
Molecular Formula	C23H19D8Cl2N3O2
Molecular Weight	~ 452.42 g/mol
Synonyms	7-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydro-2(1H)-quinolinone-D8; Aripiprazole D8 (Dehydro); Deuterated Dehydro Aripiprazole; Aripiprazole-d8 Internal Standard; OPC-14597 D8 (Dehydro); Abilify D8 (Dehydro); BMY-14802 D8 (Dehydro)
EINECS	Contact for details

Quality Control

Every batch of Dehydro Aripiprazole-D8 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. Certificates of Analysis (COA) are supplied with each shipment, detailing parameters such as chemical purity, isotopic purity (D-enrichment), and identity confirmation via spectroscopic methods. Our quality commitment ensures consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.