Description

N,n-Dideethylchloroquine-D4 is a deuterated analog of a chloroquine derivative, specifically designed for use as an analytical reference standard. This compound is essential for researchers and quality control laboratories requiring high-purity, isotopically labeled materials for precise quantification and metabolic studies. It is primarily utilized in pharmaceutical research and development, particularly in the fields of analytical chemistry, pharmacokinetics, and drug metabolism and pharmacokinetics (DMPK).

Application

• Primary use as an Internal Standard for the accurate quantification of chloroquine and its metabolites in biological matrices via LC-MS/MS.
• Critical component in Deuterium-Labeled Tracer Studies for investigating the metabolic pathways and pharmacokinetic profiles of antimalarial agents.
• Reference material for Method Development and Validation in bioanalytical laboratories to ensure regulatory compliance (e.g., FDA, EMA).
• Used in Stable Isotope Dilution Assays to enhance analytical precision and accuracy in complex sample analysis.
• Essential for Pharmaceutical Impurity Profiling and characterization of related substances in active pharmaceutical ingredient (API) batches.
• Supporting material for Academic and Contract Research focused on antimalarial drug mechanisms and resistance studies.

Basic Information

Product Name	N,n-Dideethylchloroquine-D4
CAS No.	1215797-41-3
Molecular Formula	C18H22D4ClN3
Molecular Weight	Contact for details
Synonyms	7-Chloro-4-[[4-(diethylamino-d4)-1-methylbutyl]amino]quinoline; N1,N1-Diethyl-d4-chloroquine; Chloroquine-d4 (N,N-dideethyl); Deuterated Chloroquine Derivative; N,N-Dideethylchloroquine-d4; 4-[(4-Diethylamino-d4-1-methylbutyl)amino]-7-chloroquinoline; Isotopically Labeled Chloroquine Impurity/Intermediate
EINECS	Contact for details

Quality Control

Every batch of N,n-Dideethylchloroquine-D4 is manufactured and analyzed under strict quality systems to ensure identity, purity, and isotopic enrichment meet the exacting standards required for analytical applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical data is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.