Description

α-Desmethyl Anastrozole CAS NO 1215780-15-6 is a key pharmaceutical intermediate and metabolite of the aromatase inhibitor anastrozole. This compound is of significant value in the research and development of therapeutic agents targeting hormone-dependent conditions. It is primarily required by pharmaceutical manufacturers and advanced research laboratories for the synthesis of active pharmaceutical ingredients (APIs) and for analytical reference standards in pharmacokinetic and metabolic studies.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of aromatase inhibitors and related steroidal compounds.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development and validation.
• Metabolite Studies: Essential for drug metabolism and pharmacokinetics (DMPK) research to understand the biotransformation of anastrozole.
• Impurity Profiling: Serves as a known impurity standard in the quality control of anastrozole API batches to ensure purity and compliance.
• Biochemical Research: Utilized in studies investigating estrogen biosynthesis and the mechanism of aromatase enzyme inhibition.

Basic Information

Product Name	α-Desmethyl Anastrozole
CAS No.	1215780-15-6
Molecular Formula	C16H17N5
Molecular Weight	279.35 g/mol
Synonyms	2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropiononitrile); Desmethyl Anastrozole; Anastrozole Impurity F; Anastrozole Metabolite; 1,3-Bis(2-cyano-2-propyl)-5-((1H-1,2,4-triazol-1-yl)methyl)benzene; ZD1033 Metabolite; Arimidex Metabolite
EINECS	Contact for details

Quality Control

Our α-Desmethyl Anastrozole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.