Description

Zolpidem-D6 6-Carboxylic Acid Methyl Ester is a high-purity, stable isotope-labeled derivative of zolpidem, a widely prescribed sedative-hypnotic. This compound is specifically designed for use as a critical internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units that require precise and reproducible analytical data for regulatory submissions and quality control.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application as a deuterated internal standard for the accurate quantification of zolpidem and its metabolites in biological matrices (plasma, serum, urine).
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of zolpidem.
• Forensic Toxicology: Enables precise measurement of zolpidem levels in forensic investigations, supporting cases of driving under the influence or overdose analysis.
• Bioequivalence Studies: Critical for comparing the bioavailability of generic zolpidem formulations against the branded reference product.
• Metabolite Identification: Aids in the structural elucidation and quantification of zolpidem metabolites during drug metabolism studies.
• Method Development & Validation: Serves as a key component in developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.

Basic Information

Product Name	Zolpidem-D6 6-Carboxylic Acid Methyl Ester
CAS No.	1215767-20-6
Molecular Formula	C20H15D6N3O3
Molecular Weight	~ 357.42 g/mol
Synonyms	Zolpidem-6-carboxylic acid methyl ester-D6; Methyl 2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetate-3,4,5,6,7,8-d6; Deuterated Zolpidem Carboxylic Acid Methyl Ester; Zolpidem-D6 Methyl Ester; Zolpidem metabolite standard-D6; Ambien-D6 derivative; Internal Standard for Zolpidem LC-MS
EINECS	Contact for details

Quality Control

Every batch of Zolpidem-D6 6-Carboxylic Acid Methyl Ester is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR, HPLC, and mass spectrometry to confirm identity, potency, and deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.