Description

n-Nitroso-n-(Methyl-D3)-3-Aminopropionic Acid CAS NO 1215691-18-1 is a deuterated isotopologue of a nitrosamine derivative, specifically engineered for advanced research and analytical applications. This compound is of significant value as a high-purity reference standard and a critical intermediate in metabolic and pharmacokinetic studies, particularly in the development of deuterated drug candidates. It is primarily needed by pharmaceutical R&D laboratories, analytical chemists, and contract research organizations (CROs) specializing in isotope labeling, mass spectrometry, and the investigation of nitrosamine impurities.

Application

• Deuterated Internal Standard for the precise quantification of nitrosamine impurities in active pharmaceutical ingredients (APIs) and finished drug products using LC-MS/MS.
• Metabolic Tracing Intermediate in the synthesis of deuterium-labeled compounds for studying drug metabolism and distribution pathways.
• Research Chemical for academic and industrial investigations into the chemistry, stability, and formation mechanisms of N-nitrosamines.
• Pharmaceutical Impurity Standard used in method development and validation to ensure compliance with stringent regulatory limits for genotoxic impurities (GTIs).
• Isotope-Labeled Building Block for the synthesis of more complex deuterated molecules in medicinal chemistry programs.

Basic Information

Product Name	n-Nitroso-n-(Methyl-D3)-3-Aminopropionic Acid
CAS No.	1215691-18-1
Molecular Formula	C4H4D3N2O3
Molecular Weight	147.12 g/mol
Synonyms	3-(N-Nitroso-N-(trideuteriomethyl)amino)propanoic Acid; N-Nitroso-N-(methyl-d3)-β-alanine; N-Methyl-d3-N-nitroso-3-aminopropionic Acid; Deuterated N-Nitroso-N-methyl-3-aminopropionic Acid; N-Nitroso-N-(CD3)-3-aminopropionic Acid; (Methyl-d3)nitrosamino-propionic Acid; N-Nitroso-N-(trideuteromethyl)-β-alanine
EINECS	Contact for details

Quality Control

Supplied as a high-purity analytical standard, this product undergoes rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure identity, potency, and isotopic purity. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing specifications for assay, isotopic enrichment, and related substances. Our quality system is designed to support GMP/GLP-compliant research and meets the exacting standards required for regulatory submission support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccator under an inert atmosphere for long-term storage. Handle and store in accordance with all applicable laboratory safety regulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.