Description

N10-Monodesmethyl Rizatriptan-D3 is a high-purity, deuterium-labeled internal standard critical for advanced analytical applications. This compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments for the precise analysis of rizatriptan and its metabolites.

Application

• Primary use as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis.
• Critical for bioanalytical method development and validation in clinical and preclinical studies of rizatriptan.
• Enables accurate quantification of rizatriptan and its metabolites in complex biological matrices like plasma, serum, and urine.
• Supports drug metabolism and pharmacokinetic (DMPK) research to understand absorption, distribution, metabolism, and excretion (ADME).
• Used in pharmaceutical quality control for impurity profiling and stability-indicating assays.
• Facilitates forensic and toxicological analysis for the detection and quantification of rizatriptan.

Basic Information

Product Name	N10-Monodesmethyl Rizatriptan-D3
CAS No.	1215678-02-6
Molecular Formula	C15H16D3N5
Molecular Weight	Contact for details
Synonyms	N-Desmethyl Rizatriptan-d3; 3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-7-carboxamide-d3; Rizatriptan N-Desmethyl-d3; Rizatriptan Metabolite M9-d3; N10-Desmethylrizatriptan-d3; Deuterated N-Desmethyl Rizatriptan; Rizatriptan-d3 Desmethyl Analog
EINECS	Contact for details

Quality Control

Our N10-Monodesmethyl Rizatriptan-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical work. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from advanced spectroscopic and chromatographic tests, including NMR, HPLC, and MS. We are committed to supplying materials that meet the exacting standards of modern pharmaceutical analysis and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.