Description

2-Ethoxy-3H-Benzimidazole-4-Carboxylic Acid Methyl Ester-D5 is a high-purity, deuterium-labeled derivative of a benzimidazole-based compound, serving as a critical analytical standard and synthetic intermediate. Its primary value lies in enabling precise quantification and metabolic pathway tracing in pharmaceutical research and development through advanced mass spectrometry techniques. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors who require stable isotope-labeled materials for method development, quality control, and regulatory compliance studies.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a quantitative reference standard in bioanalytical methods for pharmacokinetic and metabolism studies.
• Pharmaceutical Intermediate: Acts as a key deuterated building block in the synthesis of novel active pharmaceutical ingredients (APIs) for drug discovery programs.
• Metabolite Identification & Tracing: Facilitates the identification and tracking of metabolites in in vitro and in vivo studies due to its isotopic label.
• Agrochemical Research: Employed in the development and analysis of deuterated agrochemicals and their environmental fate.
• Quality Control & Method Validation: Serves as a certified reference material to validate analytical methods and ensure accuracy in manufacturing quality control labs.
• Isotope Dilution Mass Spectrometry (IDMS): Critical for achieving high-precision and accurate quantification in complex matrices.

Basic Information

Product Name	2-Ethoxy-3H-Benzimidazole-4-Carboxylic Acid Methyl Ester-D5
CAS No.	1215647-69-0
Molecular Formula	C11H6D5N2O3
Molecular Weight	~223.23 g/mol
Synonyms	Methyl 2-ethoxy-1H-benzimidazole-4-carboxylate-d5; Methyl 2-ethoxy-1H-benzo[d]imidazole-4-carboxylate-d5; 2-Ethoxy-1H-benzimidazole-4-carboxylic acid methyl ester-d5; Deuterated Methyl 2-ethoxybenzimidazole-4-carboxylate; 2-Ethoxy-3H-benzimidazole-4-carboxylic acid methyl ester (pentadeutero); Benzimidazole-4-carboxylic acid, 2-ethoxy-, methyl ester-d5; Stable Isotope Labeled Benzimidazole Derivative
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C), High-Resolution Mass Spectrometry (HRMS), and HPLC to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) are provided, detailing batch-specific results for isotopic enrichment (typically ≥98 atom % D), chemical purity (typically ≥95% by HPLC), and related substance profiles. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.