Description

Prochlorperazine-D8 is a deuterated internal standard of the antipsychotic and antiemetic drug Prochlorperazine, specifically designed for use in quantitative mass spectrometry. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of analytical methods in pharmaceutical research and development. It is primarily used by analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and regulatory testing laboratories for applications such as pharmacokinetic studies, bioanalytical method validation, and drug metabolism research.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the precise quantification of Prochlorperazine in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical trials.
• Bioanalytical Method Development and Validation: Used to establish robust, sensitive, and specific analytical assays compliant with FDA, EMA, and ICH guidelines.
• Drug Metabolism and Metabolite Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in metabolism studies.
• Forensic and Clinical Toxicology: Supports the accurate measurement of Prochlorperazine levels in forensic investigations or therapeutic drug monitoring.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assay methods for drug substance and product analysis.

Basic Information

Product Name	Prochlorperazine-D8
CAS No.	1215641-01-2
Molecular Formula	C₂₀H₂₀D₈ClN₃S
Molecular Weight	~ 380.0 g/mol
Synonyms	2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine-D8; Compazine-D8; Prochlorperazine (phenyl-D8); Prochlorperazine-d8; Deuterated Prochlorperazine; Prochlorperazine Internal Standard; 1-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-4-methylpiperazine-D8
EINECS	Contact for details

Quality Control

Our Prochlorperazine-D8 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is analyzed using advanced techniques including NMR (for deuterium incorporation) and HPLC/MS to confirm identity, purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for purity, assay, and solvent residues, ensuring compliance with the rigorous demands of analytical and regulatory science.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Assay (HPLC)	97.0% - 103.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.