Description

Sumatriptan-D6 Succinate is a high-purity, stable isotope-labeled internal standard of the therapeutic agent Sumatriptan, essential for precise quantitative bioanalytical measurements. This deuterated compound is critical for ensuring accuracy and reliability in pharmacokinetic and metabolism studies, where it compensates for matrix effects and instrumental variability. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development and validation for clinical and forensic analysis.

Application

• Quantitative Bioanalysis: Serves as an internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of Sumatriptan in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical trials.
• Metabolite Identification and Profiling: Used as a reference standard in mass spectrometry to identify and characterize drug metabolites.
• Method Development and Validation: A critical component for developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Forensic and Doping Control Analysis: Supports the accurate detection and quantification of Sumatriptan in forensic toxicology and anti-doping programs.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and assay verification of Sumatriptan active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Sumatriptan-D6 Succinate
CAS No.	1215621-31-0
Molecular Formula	C₁₈H₂₀D₆N₃O₂S • C₄H₆O₄
Molecular Weight	469.60 g/mol
Synonyms	Sumatriptan-d6 Succinate Salt; 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide-d6 Succinate; 1H-Indole-5-methanesulfonamide, 3-[2-(dimethylamino)ethyl]-N-methyl-, (3-2H3)-, (2,2,3,4,5,6-2H6)-, butanedioate (1:1); Deuterated Sumatriptan Succinate; Sumatriptan (phenyl-d6) Succinate; [2H6]-Sumatriptan Succinate; Internal Standard for Sumatriptan
EINECS	Contact for details

Quality Control

Every batch of Sumatriptan-D6 Succinate is manufactured and analyzed under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive mass spectrometry applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for isotopic enrichment, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.