Description

3,5-Diiodo-4-Hydroxybenzaldehyde-13C6 is a stable isotope-labeled derivative of a key phenolic aldehyde, where six carbon atoms are replaced with the carbon-13 isotope. This compound is essential as a high-purity internal standard and tracer in quantitative mass spectrometry, providing unmatched accuracy for method development and validation. It is primarily required by analytical laboratories, pharmaceutical R&D teams, and contract research organizations (CROs) engaged in advanced metabolic studies, pharmacokinetic research, and the development of sensitive bioanalytical assays.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of 3,5-Diiodo-4-Hydroxybenzaldehyde and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolic Pathway Tracing: Used in isotope dilution studies to elucidate drug metabolism and degradation pathways in pharmaceutical development.
• Biomarker Research: Enables accurate measurement of phenolic aldehyde biomarkers in clinical and preclinical studies.
• Method Development & Validation: Serves as a reference standard to establish selectivity, sensitivity, linearity, and reproducibility in new analytical methods.
• Quality Control in API Synthesis: Employed to monitor reaction intermediates and ensure the quality of active pharmaceutical ingredient (API) batches.
• Environmental Analysis: Can be used as a tracer in environmental fate studies of halogenated phenolic compounds.

Basic Information

Product Name	3,5-Diiodo-4-Hydroxybenzaldehyde-13C6
CAS No.	1215600-52-4
Molecular Formula	13C6H3I2O2
Molecular Weight	~406.90 (for 13C6)
Synonyms	4-Hydroxy-3,5-diiodobenzaldehyde-13C6; 3,5-Diiodo-4-hydroxybenzaldehyde-13C6; 13C6-Labeled 3,5-Diiodo-4-hydroxybenzaldehyde; 3,5-Diiodo-4-formylphenol-13C6; 4-Formyl-2,6-diiodophenol-13C6; DIHB-13C6; Stable Isotope Labeled DIHB
EINECS	Contact for details

Quality Control

Every batch of 3,5-Diiodo-4-Hydroxybenzaldehyde-13C6 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and mass spectrometry to confirm 13C enrichment and positional integrity. Certificates of Analysis (COA) are provided with each shipment, detailing purity, isotopic enrichment, and solvent content. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as argon or nitrogen in a sealed vial. Keep the container in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment (13C)	≥99 atom % 13C
Isotopic Purity (by MS)	≥98% (M+6)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.