Description

n-Depropyl Propafenone-D5 Oxalate Salt is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in method development and validation for drug substance analysis.

Application

• Used as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the precise quantification of propafenone and its metabolites.
• Critical for bioanalytical method development and validation in support of clinical trials and non-clinical studies.
• Enables accurate pharmacokinetic (PK) and pharmacodynamic (PD) profiling of antiarrhythmic agents.
• Supports drug metabolism and excretion studies by providing a stable isotopic reference for mass spectrometric detection.
• Facilitates impurity profiling and stability testing of pharmaceutical active ingredients.
• Employed in forensic and clinical toxicology for the definitive identification and measurement of propafenone.

Basic Information

Product Name	n-Depropyl Propafenone-D5 Oxalate Salt
CAS No.	1215598-59-6
Molecular Formula	C20H21D5NO5
Molecular Weight	Contact for details
Synonyms	Propafenone-d5 Metabolite M1; 1-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone-d5 Oxalate; 2'-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone-d5 Oxalate; n-Despropylpropafenone-d5 Oxalate; Propafenone N-Despropyl Metabolite-d5; Propafenone-d5 (n-Despropyl) Oxalate Salt; 3-Phenyl-1-{2-hydroxy-3-[(propyl-d5)amino]propoxy}propiophenone Oxalate
EINECS	Contact for details

Quality Control

Our n-Depropyl Propafenone-D5 Oxalate Salt is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.