Description

Butabarbital-D5 is a deuterated analog of the barbiturate derivative butabarbital, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative analytical methods, ensuring the highest accuracy and reliability in mass spectrometry. It is primarily required by analytical laboratories and pharmaceutical researchers engaged in method development, pharmacokinetic studies, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of butabarbital in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetic (DMPK) studies to track and measure the parent drug and its metabolites.
• Forensic and Clinical Toxicology: Enables accurate screening and confirmation of butabarbital in forensic investigations and clinical overdose cases.
• Method Development and Validation: Serves as a key reference material for developing, optimizing, and validating robust analytical assays in compliance with regulatory guidelines.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and stability testing of butabarbital-containing drug products.
• Reference Material for Certified Standards: Used by manufacturers of certified reference materials (CRMs) to produce traceable and accredited standards.

Basic Information

Product Name	Butabarbital-D5
CAS No.	1215565-64-2
Molecular Formula	C10H13D5N2O3
Molecular Weight	215.27 g/mol
Synonyms	5-(2-Methylpropyl)-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione-d5; 5-Ethyl-5-isobutylbarbituric acid-d5; Butisol-d5; Butethal-d5; 5-Ethyl-5-(2-methylpropyl)-1,3-diazinane-2,4,6-trione-d5; Deuterated Butabarbital; [2H5]-Butabarbital
EINECS	Contact for details

Quality Control

Every batch of Butabarbital-D5 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment, and analytical results. Our quality commitment aligns with standards expected for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.