Description

1-(Methyl-D3)-5-(3-Pyridinyl)-2-Pyrrolidinone n-Oxide is a deuterated pyrrolidinone derivative, a high-value specialty chemical used as a key intermediate or reference standard in advanced research and development. Its primary value lies in its isotopic labeling, which is critical for metabolic, pharmacokinetic, and mechanistic studies in pharmaceutical discovery. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel therapeutics where precise molecular tracking is required.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of deuterated drug candidates, leveraging the kinetic isotope effect for improved metabolic stability.
• Metabolic Research: Used as an internal standard or labeled tracer in mass spectrometry-based studies to investigate drug metabolism and disposition pathways.
• Analytical Reference Standard: Provides a certified reference material for the qualitative and quantitative analysis of active pharmaceutical ingredients (APIs) and their metabolites.
• Neurological Research: Acts as a precursor or analog in the development of compounds targeting neurological pathways, given the pyridinyl-pyrrolidinone structural motif.
• Isotope Labeling Studies: Facilitates mechanistic studies in medicinal chemistry, helping to elucidate reaction pathways and biological mechanisms through deuterium labeling.

Basic Information

Product Name	1-(Methyl-D3)-5-(3-Pyridinyl)-2-Pyrrolidinone n-Oxide
CAS No.	1215561-37-7
Molecular Formula	C10H10D3N2O2
Molecular Weight	196.23 g/mol
Synonyms	1-(Trideuteriomethyl)-5-(pyridin-3-yl)-2-pyrrolidinone 1-oxide; 5-(3-Pyridinyl)-1-(methyl-d3)-2-pyrrolidinone N-oxide; Deuterated Cotinine N-Oxide (d3); Cotinine-d3 N-Oxide; 1-Methyl-d3-5-(3-pyridyl)-2-pyrrolidinone 1-oxide; (R/S)-Cotinine-d3 N-Oxide; 3-((2-Oxo-5-(trideuteriomethyl)pyrrolidin-1-yl)oxide)pyridine
EINECS	Contact for details

Quality Control

Our 1-(Methyl-D3)-5-(3-Pyridinyl)-2-Pyrrolidinone n-Oxide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical and isotopic purity, meeting the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.