Description

Riluzole-13C,15N2 is a stable isotope-labeled analog of the neuroprotective agent Riluzole, specifically enriched with carbon-13 and nitrogen-15 isotopes. This compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in the development and quality control of neurological therapeutics, particularly for conditions like amyotrophic lateral sclerosis (ALS).

Application

• Primary use as an Internal Standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the precise quantification of Riluzole in biological matrices.
• Critical component in Pharmacokinetic (PK) and Bioequivalence Studies to track drug absorption, distribution, metabolism, and excretion.
• Enabling accurate Metabolite Identification and Profiling in drug metabolism and disposition (DMPK) research.
• Supporting Clinical Trial Analysis by providing validated reference materials for patient sample testing.
• Use in Forensic and Anti-Doping Analysis for the definitive identification and measurement of Riluzole.
• Facilitating Method Development and Validation in regulatory-compliant (FDA, EMA) analytical laboratories.
• Application in Stable Isotope Dilution Assays (SIDA) to achieve superior accuracy in complex sample analysis.

Basic Information

Product Name	Riluzole-13C,15N2
CAS No.	1215552-03-6
Molecular Formula	C713C1H5F3N15N2O2S
Molecular Weight	~237.19 g/mol
Synonyms	2-Amino-6-(trifluoromethoxy)benzothiazole-13C,15N2; 6-(Trifluoromethoxy)-2-benzothiazolamine-13C,15N2; Riluzole (13C,15N2); Rilutek-13C,15N2; RP 54274-13C,15N2; PK 26124-13C,15N2; 2-Amino-6-trifluoromethoxybenzothiazole-13C,15N2; Isotopically Labeled Riluzole
EINECS	Contact for details

Quality Control

Every batch of Riluzole-13C,15N2 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, isotopic enrichment, and identification by spectroscopic methods. Certificates of Analysis (COA) detailing all specifications, including HPLC purity, NMR, and MS data, are provided to ensure traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C; ≥99 atom % 15N
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.