Description

Cilostazol-D4 is a high-purity, deuterium-labeled analog of the antiplatelet agent Cilostazol, specifically designed for use as an internal standard in quantitative analytical methods. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic, metabolic, and bioanalytical studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the development and quality control of Cilostazol-based therapeutics.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) bioanalysis for Cilostazol.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Biomedical Research: Supports investigative studies on the mechanism of action and metabolic pathways of Cilostazol.
• Pharmaceutical Quality Control: Used in the development and validation of robust analytical methods for assay and impurity profiling of Cilostazol drug substances and products.
• Reference Standard: Serves as a certified reference material for calibrating analytical instruments and ensuring method specificity.

Basic Information

Product Name	Cilostazol-D4
CAS No.	1215541-47-1
Molecular Formula	C20H23D4N5O2
Molecular Weight	369.48 g/mol
Synonyms	6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone-d4; OPC-13013-d4; Pletal-d4 (deuterated); Cilostazol (tetradeuterated); 3,4-Dihydro-6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-2(1H)-quinolinone-d4; Cilostazol Internal Standard-d4; Cilostazol-d4 (IS)
EINECS	Contact for details

Quality Control

Our Cilostazol-D4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment (D-content), and purity by HPLC. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific pharmacopeial or client specifications is available.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.