Description

Metoprolol Acid-D5 is a deuterated analog of the key synthetic intermediate for the widely used β-blocker, Metoprolol. This high-purity compound is specifically designed for use as an internal standard in quantitative analytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the development and quality control of Metoprolol-based drug products and metabolites.

Application

• Primary use as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis.
• Critical component in bioanalytical method development and validation for Metoprolol and its metabolites in biological matrices (plasma, serum, urine).
• Enables accurate pharmacokinetic (PK) and drug metabolism studies in clinical and pre-clinical research.
• Used in impurity profiling and characterization of Metoprolol Active Pharmaceutical Ingredient (API) and finished dosage forms.
• Supports doping control analysis in sports where β-blockers are prohibited.
• Facilitates forensic and toxicological investigations requiring precise quantification of Metoprolol.

Basic Information

Product Name	Metoprolol Acid-D5
CAS No.	1215404-47-9
Molecular Formula	C15H20D5NO3
Molecular Weight	~267.38 g/mol
Synonyms	1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol-2,2,3,3,3-d5 Acid; 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic Acid-d5; Metoprolol Carboxylic Acid-d5; Metoprolol Acid Deuterated; Metoprolol-d5 Acid; α-Hydroxy-β-(isopropylamino)propyl 4-(2-methoxyethyl)phenylether-d5 Carboxylic Acid; Deuterated Metoprolol Acid Intermediate
EINECS	Contact for details

Quality Control

Our Metoprolol Acid-D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, MS, and HPLC. A comprehensive Certificate of Analysis (COA) is provided, detailing purity (by HPLC), isotopic enrichment (by MS), and confirming structural identity. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.