Description

Dehydro Aripiprazole-D8, Hydrochloride is a high-purity, deuterium-labeled internal standard critical for advanced analytical applications. This compound is specifically designed to ensure accuracy and reliability in quantitative mass spectrometry, providing a stable isotopic reference for the quantification of aripiprazole and its metabolites. It is an essential tool for pharmaceutical research and development, clinical laboratories, and forensic toxicology programs requiring precise bioanalytical method development and validation.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the precise quantification of aripiprazole and its dehydro metabolite in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust clinical assays to monitor aripiprazole levels in patients for dose optimization.
• Forensic & Clinical Toxicology: Used in confirmatory testing and method development for the detection of antipsychotic medications in forensic and clinical settings.
• Pharmaceutical R&D: Facilitates impurity profiling, stability testing, and the characterization of drug substances and products during development.
• Reference Standard Manufacturing: Acts as a certified reference material (CRM) for calibrating analytical instruments and validating testing methods in quality control laboratories.

Basic Information

Product Name	Dehydro Aripiprazole-D8, Hydrochloride
CAS No.	1215383-78-0
Molecular Formula	C23H19D8Cl2N3O2 • HCl
Molecular Weight	~ 492.88 g/mol
Synonyms	7-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydro-2(1H)-quinolinone-d8 Hydrochloride; Dehydro Aripiprazole D8 HCl; Aripiprazole Dehydro Metabolite-d8 Hydrochloride; OPC-14597 Dehydro Metabolite-d8 Hydrochloride; 7-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydrocarbostyril-d8 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Dehydro Aripiprazole-D8, Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with the high-purity standards required for analytical reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for chemical purity, isotopic enrichment, and identity.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.