Description

5-Hydroxy Propafenone-D5 Hydrochloride is a high-purity, isotopically labeled internal standard critical for advanced analytical chemistry and pharmaceutical research. This deuterated compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by research institutions, pharmaceutical developers, and contract research organizations (CROs) engaged in the development and quality control of cardiovascular drugs.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the precise quantification of propafenone and its metabolites in complex biological matrices like plasma and serum.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used as a key component in developing robust, sensitive, and specific analytical assays compliant with FDA and ICH guidelines.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during drug substance manufacturing.
• Clinical Trial Support: Provides reliable data for therapeutic drug monitoring and establishing dose-concentration relationships in clinical studies.
• Reference Material for Certified Standards: Acts as a primary material for the preparation of certified reference standards used in quality control laboratories.

Basic Information

Product Name	5-Hydroxy Propafenone-D5 Hydrochloride
CAS No.	1215370-87-8
Molecular Formula	C21H22D5ClNO3
Molecular Weight	Contact for details
Synonyms	1-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone-d5 Hydrochloride; 5-Hydroxypropafenone-d5 HCl; Propafenone Hydroxy Metabolite-D5 Hydrochloride; 5-OH-Propafenone-D5 HCl; 5-Hydroxy Propafenone (phenyl-d5) Hydrochloride; Deuterated 5-Hydroxy Propafenone HCl
EINECS	Contact for details

Quality Control

Every batch of 5-Hydroxy Propafenone-D5 Hydrochloride is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR (¹H, ¹³C), Mass Spectrometry (HRMS), and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (by HPLC), chemical purity, isotopic enrichment, and other critical parameters to meet the stringent requirements of analytical and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.