Description

Desmethyl Thiosildenafil-D8 is a high-purity, deuterated analog of a thio-derivative sildenafil metabolite, identified by CAS NO 1215321-44-0. This compound is of critical importance as a certified reference standard for analytical and research applications, ensuring accuracy and traceability in quantitative measurements. It is primarily needed by pharmaceutical R&D laboratories, forensic analysis units, and quality control departments for method development, validation, and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a primary certified standard for the quantification of metabolites in pharmacokinetic and bioequivalence studies.
• Forensic Analysis: Used as a critical calibrant in the detection and confirmation of pharmaceutical adulterants or unapproved analogs in forensic toxicology.
• Metabolite Research: Enables precise tracking and study of metabolic pathways and degradation products in preclinical and clinical research.
• Quality Control & Method Validation: Essential for developing and validating robust analytical methods (e.g., LC-MS/MS, HPLC) in pharmaceutical quality assurance laboratories.
• Doping Control: Employed by anti-doping agencies as a reference material for accurate screening and confirmation of banned substances in sports.
• Stable Isotope Labeling Studies: The deuterium (D8) labeling makes it an ideal internal standard for mass spectrometry, minimizing matrix effects and improving analytical precision.

Basic Information

Product Name	Desmethyl Thiosildenafil-D8
CAS No.	1215321-44-0
Molecular Formula	C21H22D8N6O3S2
Molecular Weight	474.66 g/mol (approx.)
Synonyms	Thiosildenafil N-Desmethyl-D8; 5-[2-Ethoxy-5-[(4-methylpiperazin-1-yl-D8)sulfonyl]phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; Desmethyl Thio-Sildenafil D8; Deuterated Desmethyl Thiosildenafil; D8-Desmethyl Thiosildenafil; N-Desmethyl Thiosildenafil-d8; PDE-5 Inhibitor Metabolite-D8
EINECS	Contact for details

Quality Control

Our Desmethyl Thiosildenafil-D8 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and isotopic enrichment meet the highest standards for reference materials. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D8)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.