Description

Ethyl 2-(2,5-Dichlorophenyl)-2,2-Difluoroacetate is a high-purity fluorinated and chlorinated aromatic ester building block of significant interest in advanced organic synthesis. Its unique difluoroacetate ester group adjacent to a dichlorinated aromatic ring makes it a valuable precursor for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates requiring fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Serves as a critical building block for creating novel herbicides, fungicides, and insecticides, where the dichlorophenyl and difluoroacetate groups can contribute to biological activity.
• Material Science Research: Used in the development of specialty polymers and advanced organic materials that benefit from the incorporation of halogenated aromatic units.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological systems, leveraging its potential for further functionalization.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	Ethyl 2-(2,5-Dichlorophenyl)-2,2-Difluoroacetate
CAS No.	1215206-21-5
Molecular Formula	C10H8Cl2F2O2
Molecular Weight	265.07 g/mol
Synonyms	2,2-Difluoro-2-(2,5-dichlorophenyl)acetic Acid Ethyl Ester; Ethyl 2,2-Difluoro-2-(2,5-dichlorophenyl)acetate; Acetic acid, 2-(2,5-dichlorophenyl)-2,2-difluoro-, ethyl ester; Ethyl (2,5-dichlorophenyl)difluoroacetate; 1215206-21-5; Ethyl α,α-difluoro-2,5-dichlorophenylacetate
EINECS	Contact for details

Quality Control

Our Ethyl 2-(2,5-Dichlorophenyl)-2,2-Difluoroacetate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.