Description

(2S)-2-Amino-6-{[(Prop-2-Yn-1-Yloxy)Carbonyl]Amino}Hexanoic Acid is a specialized, non-natural amino acid derivative featuring a reactive alkyne handle, making it a critical building block for advanced bioconjugation and chemical biology research. Its core value lies in enabling the site-specific modification of peptides, proteins, and other biomolecules through robust click chemistry reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC). This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and materials science who require precise and stable linkages for creating novel drug conjugates, diagnostic probes, and functional biomaterials.

Application

• Peptide & Protein Conjugation: Site-specific incorporation of fluorescent dyes, affinity tags (e.g., biotin), or drug payloads onto biomolecules via click chemistry.
• Antibody-Drug Conjugate (ADC) Development: Serves as a key linker component for constructing stable, homogeneous ADCs with controlled drug-to-antibody ratios.
• Chemical Biology Probes: Synthesis of activity-based probes (ABPs) and photoaffinity labels for target identification and enzyme profiling studies.
• Biomaterial Functionalization: Modification of polymer surfaces, hydrogels, and nanoparticles to introduce bioactive motifs for tissue engineering and drug delivery systems.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected or unprotected amino acid building block to introduce alkyne functionality directly into peptide sequences.
• Diagnostic Reagent Synthesis: Creation of contrast agents and molecular imaging probes for modalities like PET and fluorescence imaging.

Basic Information

Product Name	(2S)-2-Amino-6-{[(Prop-2-Yn-1-Yloxy)Carbonyl]Amino}Hexanoic Acid
CAS No.	1215204-46-8
Molecular Formula	C10H15N3O4
Molecular Weight	241.25 g/mol
Synonyms	N6-(Prop-2-yn-1-yloxycarbonyl)-L-lysine; Nε-Propargyloxycarbonyl-L-lysine; Nε-Poc-L-Lysine; L-Lysine, N6-[(2-propyn-1-yloxy)carbonyl]-; Alkyne-functionalized L-Lysine derivative; Click chemistry amino acid; Poc-Lys-OH; (S)-2-Amino-6-((prop-2-yn-1-yloxy)carbonylamino)hexanoic acid
EINECS	Contact for details

Quality Control

Our (2S)-2-Amino-6-{[(Prop-2-Yn-1-Yloxy)Carbonyl]Amino}Hexanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.