Description

(2S,3R)-3-tert-Butyl-2-(Di-tert-Butylphosphino)-4-Methoxy-2,3-Dihydrobenzo[D][1,3]Oxaphosphole CAS NO 1215081-28-9 is a highly specialized, chiral phosphine-oxazoline hybrid ligand, prized for its ability to induce exceptional enantioselectivity in transition metal-catalyzed reactions. Its value lies in enabling the synthesis of complex, single-enantiomer molecules with high efficiency and precision, which is critical for developing advanced pharmaceuticals and agrochemicals. This compound is essential for R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries who require reliable, high-performance catalysts for asymmetric synthesis.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing chiral intermediates in pharmaceutical synthesis.
• Asymmetric C-C Bond Formation: Catalyzes key reactions such as Heck couplings, Suzuki-Miyaura cross-couplings, and allylic alkylations with high stereocontrol.
• Pharmaceutical Intermediate Synthesis: Enables the production of enantiomerically pure active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Product Development: Used in the synthesis of chiral herbicides, fungicides, and pesticides where biological activity is often enantiomer-specific.
• Academic & Industrial R&D: A valuable tool for methodology development in academic laboratories and for scaling up novel catalytic processes in industrial settings.
• Catalyst Library Development: Serves as a key component in high-throughput screening libraries for discovering new asymmetric transformations.

Basic Information

Item	Detail
Product Name	(2S,3R)-3-tert-Butyl-2-(Di-tert-Butylphosphino)-4-Methoxy-2,3-Dihydrobenzo[D][1,3]Oxaphosphole
CAS No.	1215081-28-9
Molecular Formula	C21H36NO2P2
Molecular Weight	396.47 g/mol
Synonyms	t-Bu-PHOX; (S,R)-t-Bu-PHOX; (2S,3R)-3-(tert-Butyl)-2-(di-tert-butylphosphanyl)-4-methoxy-2,3-dihydro-1,3-benzoxaphosphole; tert-ButylPHOX Ligand; Chiral PHOX Ligand; Phosphino-oxazoline Ligand; Asymmetric Hydrogenation Ligand
EINECS	Contact for details

Quality Control

Every batch of our (2S,3R)-3-tert-Butyl-2-(Di-tert-Butylphosphino)-4-Methoxy-2,3-Dihydrobenzo[D][1,3]Oxaphosphole is manufactured and tested under strict quality management systems. We guarantee high chemical and enantiomeric purity through comprehensive analytical techniques including NMR, HPLC, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, and specific rotation are provided with each shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity, this compound is easily oxidized and must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.