Description

4-Fluoro-2-(Difluoromethyl)Anisole is a fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is crucial for modulating biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where fluorination enhances efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the development of fluorinated components for electronic display technologies and organic light-emitting diodes.
• Functional Material Research: Employed in creating specialty polymers and coatings with unique surface properties and chemical resistance.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the properties of fluorinated arenes.

Basic Information

Product Name	4-Fluoro-2-(Difluoromethyl)Anisole
CAS No.	1214379-81-3
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	1-Fluoro-4-methoxy-2-(difluoromethyl)benzene; 2-(Difluoromethyl)-4-fluoroanisole; 4-Fluoro-2-(difluoromethyl)-1-methoxybenzene; Benzene, 1-fluoro-4-methoxy-2-(difluoromethyl)-; Anisole, 4-fluoro-2-(difluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(Difluoromethyl)Anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to guarantee supply consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential concentration changes.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0% Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.