Description

3-Bromo-4-(Difluoromethyl)Anisole is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromine and difluoromethyl substituents on an anisole core, makes it a critical intermediate for introducing specific functionalities into target molecules. This compound is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of fluorinated motifs on the physicochemical properties of organic compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated anisole derivatives.

Basic Information

Product Name	3-Bromo-4-(Difluoromethyl)Anisole
CAS No.	1214379-79-9
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	1-Bromo-2-methoxy-5-(difluoromethyl)benzene; 3-Bromo-4-(difluoromethoxy)benzene (common misnomer); 2-Methoxy-5-(difluoromethyl)-1-bromobenzene; Anisole, 3-bromo-4-(difluoromethyl)-; 5-Bromo-2-(difluoromethyl)anisole; Benzene, 1-bromo-2-methoxy-5-(difluoromethyl)-; 4-(Difluoromethyl)-3-bromoanisole
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-4-(Difluoromethyl)Anisole is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong acids and oxidizing agents. The compound is stable under recommended storage conditions.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.