Description

1-(Difluoromethoxy)-4-Fluoro-2-Methyl-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoromethoxy and fluoro substituents, enabling precise molecular modifications. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display and lighting technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and other transformations to introduce the difluoromethoxyaryl moiety into complex molecules.
• Chemical Research & Development: Utilized in academic and industrial labs for exploring new fluorination methodologies and creating compound libraries for screening.

Basic Information

Product Name	1-(Difluoromethoxy)-4-Fluoro-2-Methyl-Benzene
CAS No.	1214378-64-9
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	4-Fluoro-2-methyl-1-(difluoromethoxy)benzene; 1-Difluoromethoxy-4-fluoro-2-methylbenzene; 2-Methyl-4-fluoro-1-(difluoromethoxy)benzene; 4-Fluoro-2-methylphenyl difluoromethyl ether; α,α-Difluoro-4-fluoro-2-methylanisole
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-4-Fluoro-2-Methyl-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.