Description

3-Chloro-2-Trifluoromethylanisole is a high-value fluorinated aromatic building block characterized by its unique trifluoromethyl and chloro substituents. This compound matters for its role in facilitating the synthesis of complex molecules, particularly in the development of advanced agrochemicals and pharmaceuticals where fluorine incorporation is critical for enhancing biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a critical precursor for novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display materials, where its structure contributes to desired dielectric and optical properties.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Facilitates various cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions in complex multi-step syntheses.
• Chemical Research & Development: Essential for academic and industrial research exploring new fluorination methodologies and the structure-activity relationships of fluorinated aromatics.

Basic Information

Product Name	3-Chloro-2-Trifluoromethylanisole
CAS No.	1214377-05-5
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	1-Chloro-3-methoxy-2-(trifluoromethyl)benzene; 3-Chloro-2-(trifluoromethyl)anisole; 2-Trifluoromethyl-3-chloroanisole; 3-Chloro-alpha,alpha,α-trifluoro-o-anisole; Benzene, 1-chloro-3-methoxy-2-(trifluoromethyl)-; 3-Chloro-2-trifluoromethoxyanisole (common misnomer); 2-Chloro-6-methoxybenzotrifluoride (isomeric check); o-Anisole, 3-chloro-2-trifluoromethyl-
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Trifluoromethylanisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment. We support compliance with relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.