Description

3-Nitro-4-(trifluoromethoxy)benzonitrile is a high-value, multi-functional aromatic intermediate featuring both nitro and trifluoromethoxy substituents on a benzonitrile core. This compound matters for its role in facilitating the synthesis of complex molecules, particularly in advanced material science and pharmaceutical research where the introduction of fluorine atoms and nitrile groups is critical for modulating biological activity and material properties. It is primarily needed by R&D chemists and process development scientists in the agrochemical and pharmaceutical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, where the trifluoromethoxy group can enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity imparted by the nitro and trifluoromethoxy groups.
• Liquid Crystal & OLED Material Research: Serves as a precursor for constructing advanced organic electronic materials, where its aromatic structure and polar groups contribute to desired electronic and self-assembly properties.
• Functional Polymer Monomer: Employed in the development of specialty polymers with unique chemical resistance, thermal stability, or optical characteristics.
• Chemical Biology Probe Development: Utilized as a scaffold for creating molecular probes and tags used in biochemical assays and diagnostic research.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to the presence of the reactive nitro group adjacent to the cyano functionality.

Basic Information

Product Name	3-Nitro-4-(trifluoromethoxy)benzonitrile
CAS No.	1214360-38-9
Molecular Formula	C8H3F3N2O3
Molecular Weight	232.12 g/mol
Synonyms	4-(Trifluoromethoxy)-3-nitrobenzonitrile; 3-Nitro-4-trifluoromethoxybenzonitrile; Benzonitrile, 3-nitro-4-(trifluoromethoxy)-; 3-Nitro-α,α,α-trifluoro-p-anisonitrile; 4-Cyano-2-nitro-1-(trifluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 3-Nitro-4-(trifluoromethoxy)benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.