Description

1-Fluoro-2-Methoxy-3-(Trifluoromethyl)Benzene is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and methoxy substituents, which are critical for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials, improving charge transport and stability.
• Functional Material Development: Employed in creating specialty polymers and ligands for catalysis, where its aromatic core and substituents fine-tune material properties.
• Cross-Coupling Reactions: An effective substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	1-Fluoro-2-Methoxy-3-(Trifluoromethyl)Benzene
CAS No.	1214351-59-3
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	2-Fluoro-6-Methoxybenzotrifluoride; 3-(Trifluoromethyl)-2-fluoroanisole; 2-Fluoro-α,α,α-trifluoro-6-methoxytoluene; 1-Fluoro-2-methoxy-3-trifluoromethylbenzene; 2-Methoxy-6-(trifluoromethyl)fluorobenzene; 6-Methoxy-2-(trifluoromethyl)fluorobenzene; Benzene, 1-fluoro-2-methoxy-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-Fluoro-2-Methoxy-3-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical properties are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.5%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.35 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.