Description

2-Bromo-4-Chloro-1-(Difluoromethoxy)Benzene is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and a difluoromethoxy substituent, makes it a valuable precursor for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Serves as a crucial building block for the synthesis of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and in the synthesis of advanced materials with specific electronic characteristics.
• Fluorinated Compound Research: An important starting material for introducing the difluoromethoxy moiety into more complex fluorinated molecules, a common strategy in modern medicinal chemistry.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological systems and mechanisms of action.

Basic Information

Product Name	2-Bromo-4-Chloro-1-(Difluoromethoxy)Benzene
CAS No.	1214348-81-8
Molecular Formula	C7H4BrClF2O
Molecular Weight	257.46 g/mol
Synonyms	1-Bromo-3-Chloro-4-(Difluoromethoxy)Benzene; 2-Bromo-4-Chloro-α,α-Difluoroanisole; 4-Chloro-2-Bromo-1-(Difluoromethoxy)Benzene; Benzene, 2-bromo-4-chloro-1-(difluoromethoxy)-; 2-Bromo-4-chloro-α,α-difluoroanisole; 1-(Difluoromethoxy)-2-bromo-4-chlorobenzene; (2-Bromo-4-chlorophenyl)(difluoro)methyl ether
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Chloro-1-(Difluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Purity (HPLC/GC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.