Description

1-Bromo-3-Methoxy-2-(Trifluoromethyl)Benzene is a high-value, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound is critical for introducing bromine and trifluoromethyl substituents in a single, controlled step, enabling the rapid construction of complex molecular architectures. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for applications in drug discovery, crop protection, and specialty polymer synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogen and fluorine motifs for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group is a common pharmacophore for efficacy.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, contributing to the molecular framework of liquid crystal displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form new carbon-carbon bonds.
• Fluorine Chemistry Research: An essential reagent for studying structure-activity relationships (SAR) in medicinal chemistry due to the unique properties imparted by the trifluoromethyl group.
• Specialty Polymer Monomer: Can be incorporated into polymer backbones to create materials with specific thermal, chemical, or optical properties.

Basic Information

Product Name	1-Bromo-3-Methoxy-2-(Trifluoromethyl)Benzene
CAS No.	1214345-25-1
Molecular Formula	C9H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	2-Bromo-6-Methoxybenzotrifluoride; 3-Methoxy-2-(trifluoromethyl)bromobenzene; 2-(Trifluoromethyl)-3-methoxybromobenzene; 1-Bromo-3-methoxy-2-(trifluoromethyl)benzene; Benzene, 1-bromo-3-methoxy-2-(trifluoromethyl)-; 2-Bromo-α,α,α-trifluoro-6-methoxytoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Methoxy-2-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.