Description

2-Chloro-4-(Trifluoromethyl)Anisole, 97% is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its trifluoromethyl and chloro substituents, which are key motifs for modulating the lipophilicity, metabolic stability, and electronic properties of target molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Functional Material Development: Employed in creating specialty polymers, coatings, and advanced resins with specific chemical resistance and thermal properties.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A valuable reagent in academic and industrial labs for exploring new fluorination methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	2-Chloro-4-(Trifluoromethyl)Anisole, 97%
CAS No.	1214340-18-7
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	1-Chloro-2-methoxy-5-(trifluoromethyl)benzene; 2-Chloro-α,α,α-trifluoro-p-anisole; 2-Chloro-4-(trifluoromethyl)methoxybenzene; 2-Chloro-4-trifluoromethylanisole; 4-Trifluoromethyl-2-chloroanisole; 2-Methoxy-5-(trifluoromethyl)chlorobenzene; 5-Chloro-2-methoxybenzotrifluoride; 2-Chloro-4-(trifluoromethyl)phenyl methyl ether
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Trifluoromethyl)Anisole, 97% is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the specified 97% minimum purity and consistent impurity profile. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.