Description

4-Chloro-4-Fluoro-2-(Trifluoromethyl)-1,1-Biphenyl is a high-value, multi-functional aromatic intermediate featuring a unique halogenated biphenyl core structure. This compound is critical for advanced organic synthesis, particularly in the development of complex molecules where precise electronic and steric properties are required. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl and halogen groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for the development of specialty chemicals used in electronic displays, leveraging its rigid biphenyl structure.
• Organic Ligand & Catalyst Development: Employed in the creation of novel ligands for transition metal catalysis in cross-coupling and other fine chemical reactions.
• Polymer & Material Science: Acts as a monomer or modifier for high-performance polymers, imparting specific thermal and chemical resistance properties.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, including fluorination and cross-coupling reaction research.

Basic Information

Product Name	4-Chloro-4-Fluoro-2-(Trifluoromethyl)-1,1-Biphenyl
CAS No.	1214334-97-0
Molecular Formula	C13H7ClF4
Molecular Weight	274.64 g/mol
Synonyms	4-Chloro-4'-fluoro-2'-(trifluoromethyl)-1,1'-biphenyl; 4-Chloro-4'-fluoro-2'-(trifluoromethyl)biphenyl; 2-(Trifluoromethyl)-4-chloro-4'-fluorobiphenyl; [1,1'-Biphenyl]-4-carbonitrile, 4-chloro-4'-fluoro-2'-(trifluoromethyl)-; 4-Chloro-4-fluoro-2-(trifluoromethyl)biphenyl
EINECS	Contact for details

Quality Control

Our 4-Chloro-4-Fluoro-2-(Trifluoromethyl)-1,1-Biphenyl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.