Description

1-Bromo-2-(Difluoromethyl)-4-Methoxybenzene is a high-purity, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound is valued for its unique combination of bromine and difluoromethyl substituents, which enable precise molecular modifications in complex organic syntheses. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the difluoromethyl group for enhanced bioactivity and metabolic stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, where the introduction of fluorine atoms can modify material properties like thermal stability and dielectric constant.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl structures.
• Fluorine Chemistry Exploration: An important reagent for studying the effects of fluorination on molecular conformation, lipophilicity, and binding affinity in medicinal chemistry programs.
• Fine Chemical Production: Employed in the multi-step synthesis of complex dyes, pigments, and other high-value specialty chemicals.

Basic Information

Product Name	1-Bromo-2-(Difluoromethyl)-4-Methoxybenzene
CAS No.	1214329-81-3
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	2-Bromo-1-(difluoromethyl)-4-methoxybenzene; 4-Methoxy-2-(difluoromethyl)phenyl bromide; Benzene, 1-bromo-2-(difluoromethyl)-4-methoxy-; 1-Bromo-2-difluoromethyl-4-methoxybenzene; 2-(Difluoromethyl)-4-methoxybromobenzene; 4-Methoxy-α,α-difluoro-o-bromotoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(Difluoromethyl)-4-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.