Description

3-Methoxy-4-(Trifluoromethyl)Benzamide, 97% is a high-purity trifluoromethylated aromatic amide building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where the trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A versatile building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing advanced functional materials used in display technologies and organic electronics.
• Cross-Coupling Reactions: The aromatic ring and amide functionality make it a suitable substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Medicinal Chemistry SAR Studies: Employed to explore structure-activity relationships by introducing the methoxy and trifluoromethyl pharmacophores into lead compounds.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) and CDMOs producing specialized compounds for client projects.

Basic Information

Product Name	3-Methoxy-4-(Trifluoromethyl)Benzamide, 97%
CAS No.	1214328-36-5
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	3-Methoxy-4-(trifluoromethyl)benzamide; 4-(Trifluoromethyl)-3-methoxybenzamide; 3-Methoxy-α,α,α-trifluoro-p-toluamide; Benzamide, 3-methoxy-4-(trifluoromethyl)-; 1214328-36-5; 3-Methoxy-4-trifluoromethylbenzamide
EINECS	Contact for details

Quality Control

Our 3-Methoxy-4-(Trifluoromethyl)Benzamide, 97% is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the specified 97% minimum purity. A detailed Certificate of Analysis (COA) documenting all test results is provided with each shipment and is available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.