Description

2-[(tert-Butoxycarbonyl)Amino]-3-(3,4-Difluorophenyl)Propanoic Acid is a high-purity, protected amino acid derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in enabling the controlled construction of complex peptide and peptidomimetic structures, which are essential for pharmaceutical research and development. This compound is specifically designed for use by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries, where it facilitates the discovery and scalable production of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the solid-phase and solution-phase synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetics Development: Used to create non-natural peptide analogs with enhanced metabolic stability, bioavailability, and target specificity for therapeutic applications.
• Protease Inhibitor Synthesis: Incorporated into the backbone of molecules designed to inhibit specific enzymes, relevant for antiviral, anticancer, and anti-inflammatory drug discovery.
• Chemical Biology Research: Employed as a tool compound for studying protein-protein interactions and developing biochemical probes.
• Agrochemical Research: Serves as a building block for developing novel peptide-inspired pesticides and herbicides.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	2-[(tert-Butoxycarbonyl)Amino]-3-(3,4-Difluorophenyl)Propanoic Acid
CAS No.	1214041-87-8
Molecular Formula	C₁₄H₁₇F₂NO₄
Molecular Weight	301.29 g/mol
Synonyms	Boc-3,4-difluoro-DL-phenylalanine; N-Boc-3-(3,4-difluorophenyl)alanine; 3-(3,4-Difluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; 2-[(tert-Butoxycarbonyl)amino]-3-(3,4-difluorophenyl)propionic acid; Boc-DifluoroPhe-OH; N-tert-Butoxycarbonyl-3,4-difluorophenylalanine; (RS)-2-[(tert-Butoxycarbonyl)amino]-3-(3,4-difluorophenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our 2-[(tert-Butoxycarbonyl)Amino]-3-(3,4-Difluorophenyl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.