Description

Fmoc-β-Methyl-Dl-Phenylalanine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This compound is a critical building block in Solid-Phase Peptide Synthesis (SPPS), where it enables the controlled introduction of a β-methylated phenylalanine moiety to modify peptide structure and function. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of a sterically hindered, β-methylated phenylalanine analog into peptide chains.
• Peptidomimetic Drug Discovery: Used to create modified peptide backbones that enhance metabolic stability, bioavailability, and receptor selectivity for potential therapeutics.
• Research & Development of Bioactive Peptides: Serves as a crucial reagent in academic and industrial labs for studying structure-activity relationships (SAR) in peptide science.
• Combinatorial Chemistry Libraries: Employed to generate diverse arrays of novel compounds for high-throughput screening against biological targets.
• Synthesis of Custom Amino Acids: Acts as a precursor for further chemical modifications to create specialized, non-proteinogenic amino acids.

Basic Information

Product Name	Fmoc-β-Methyl-Dl-Phenylalanine
CAS No.	1214028-21-3
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-β-Me-DL-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-3-phenyl-DL-alanine; Fmoc-3-methyl-3-phenyl-DL-alanine; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methyl-3-phenylpropanoic acid; N-Fmoc-3-methyl-DL-phenylalanine; Fmoc-DL-β-methylphenylalanine; Fmoc-3-methyl-DL-phenylalanine; DL-Fmoc-β-methylphenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-β-Methyl-Dl-Phenylalanine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.