Description

n-[(1,1-Dimethylethoxy)Carbonyl]-4-[[(1,1-Dimethylethoxy)Carbonyl]Amino]- L-Phenylalanine is a protected amino acid derivative, specifically a Boc-protected L-phenylalanine analog, serving as a critical building block in advanced organic synthesis. Its primary value lies in providing orthogonal protection for both the amine and carboxylic acid functional groups, enabling precise, sequential reactions in complex molecule assembly. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of peptide-based therapeutics, active pharmaceutical ingredients (APIs), and novel chemical entities.

Application

• Peptide Synthesis: A key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS) for constructing complex peptide chains.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing modified phenylalanine residues.
• Bioconjugation Chemistry: Serves as a precursor for creating linkers and modified amino acids used in antibody-drug conjugates (ADCs) and other bioconjugates.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery.
• Proteomics Research: Utilized in the synthesis of isotopically labeled peptides or peptide analogs for mass spectrometry and metabolic studies.
• Material Science: Can be incorporated into specialty polymers or biomaterials that require specific amino acid functionalities.

Basic Information

Item	Details
Product Name	n-[(1,1-Dimethylethoxy)Carbonyl]-4-[[(1,1-Dimethylethoxy)Carbonyl]Amino]- L-Phenylalanine
CAS No.	1213873-71-2
Molecular Formula	C20H28N2O6
Molecular Weight	392.45 g/mol
Synonyms	Boc-Phe(4-NH-Boc)-OH; N-Boc-4-[(tert-Butoxycarbonyl)amino]-L-phenylalanine; 4-[(tert-Butoxycarbonyl)amino]-L-phenylalanine N-carboxy anhydride (Boc) protected; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-[4-[(tert-butoxycarbonyl)amino]phenyl]propanoic acid; Boc-L-Phe(4-NHBoc)-OH; Nα,N4-Bis-Boc-L-4-aminophenylalanine; L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-
EINECS	Contact for details

Quality Control

Our n-[(1,1-Dimethylethoxy)Carbonyl]-4-[[(1,1-Dimethylethoxy)Carbonyl]Amino]- L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, confirming compliance with customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.