Description

(R)-7-(Trifluoromethyl)Chroman-4-Amine is a chiral, fluorinated chroman derivative of significant interest in advanced organic synthesis. This compound matters as a high-value, optically pure building block for pharmaceutical research and development, particularly in creating molecules with enhanced metabolic stability and bioavailability. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active pharmaceutical ingredients (APIs) and other bioactive molecules.

Application

• Key chiral intermediate in the synthesis of novel central nervous system (CNS) active pharmaceutical ingredients (APIs).
• Building block for the research and development of selective serotonin reuptake inhibitors (SSRIs) and other neuropharmacological agents.
• Precursor in the creation of fluorinated bioactive compounds for agrochemical applications, leveraging the trifluoromethyl group's properties.
• Versatile synthon for asymmetric synthesis in academic and industrial research laboratories.
• Intermediate in the development of protease inhibitor candidates and other small molecule therapeutics.
• Used in the preparation of ligands for catalysis and other specialty fine chemicals.

Basic Information

Product Name	(R)-7-(Trifluoromethyl)Chroman-4-Amine
CAS No.	1213657-96-5
Molecular Formula	C10H10F3NO
Molecular Weight	217.19 g/mol
Synonyms	(R)-7-(Trifluoromethyl)-3,4-dihydro-2H-1-benzopyran-4-amine; (4R)-7-(Trifluoromethyl)-3,4-dihydro-2H-chromen-4-amine; (R)-7-(Trifluoromethyl)-3,4-dihydro-2H-chromen-4-amine; (R)-7-(Trifluoromethyl)chroman-4-ylamine; (R)-4-Amino-7-(trifluoromethyl)chroman; (R)-7-Trifluoromethylchroman-4-amine; (R)-TFCA
EINECS	Contact for details

Quality Control

Our (R)-7-(Trifluoromethyl)Chroman-4-Amine is produced under strict quality management systems to ensure batch-to-batch consistency and high optical purity. We employ advanced analytical techniques, including chiral HPLC and NMR, to verify identity, enantiomeric excess (ee), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.