Description

Boc-D-4-Carbamoylphe CAS NO 1213639-41-8 is a protected amino acid derivative, specifically a Boc-protected form of D-4-carbamoylphenylalanine, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of a carbamoyl-functionalized aromatic side chain while maintaining stereochemical integrity under standard peptide coupling conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel peptide-based therapeutics, enzyme inhibitors, and complex molecular probes.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide drugs, protease inhibitors, and targeted therapeutics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a modified phenylalanine residue with a carbamoyl group.
• Chemical Biology: Building block for creating activity-based probes (ABPs) and photoaffinity labels to study enzyme function and protein-protein interactions.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by providing a site for further functionalization on aromatic rings in drug candidates.
• Bioconjugation: Serves as a precursor for linker molecules in antibody-drug conjugates (ADCs) and other bioconjugation strategies.
• Academic Research: Fundamental reagent for synthesizing non-natural amino acids and studying their incorporation into proteins.

Basic Information

Product Name	Boc-D-4-Carbamoylphe
CAS No.	1213639-41-8
Molecular Formula	C₁₅H₂₀N₂O₅
Molecular Weight	308.33 g/mol
Synonyms	Boc-D-4-Carbamoylphenylalanine; (R)-2-((tert-Butoxycarbonyl)amino)-3-(4-carbamoylphenyl)propanoic acid; N-(tert-Butoxycarbonyl)-D-4-carbamoylphenylalanine; Boc-D-Phe(4-CONH2)-OH; Boc-D-4-Aminocarbonylphenylalanine; tert-Butyloxycarbonyl-D-4-carbamoylphenylalanine; D-Boc-4-Carbamoylphe
EINECS	Contact for details

Quality Control

Our Boc-D-4-Carbamoylphe is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.