Description

(2R)-2-Amino-2-(3,4,5-Trifluorophenyl)Acetic Acid is a high-purity, non-natural amino acid derivative characterized by its chiral (R)-configuration and trifluoromethylphenyl side chain. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel active pharmaceutical ingredients (APIs). It is essential for research and production in the pharmaceutical and agrochemical industries, where its unique fluorinated aromatic structure is leveraged to modulate the bioavailability, metabolic stability, and binding affinity of target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Research: Used in developing advanced herbicides and pesticides where the fluorine atoms enhance lipophilicity and environmental stability.
• Peptidomimetics: Incorporated into peptide analogs to improve resistance to enzymatic degradation and enhance membrane permeability.
• Ligand Synthesis: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Diagnostic Reagents: Potential use in the development of fluorinated probes and contrast agents for imaging applications.
• Academic & R&D: A valuable reagent for medicinal chemistry research and process development in university and corporate laboratories.

Basic Information

Product Name	(2R)-2-Amino-2-(3,4,5-Trifluorophenyl)Acetic Acid
CAS No.	1213483-86-3
Molecular Formula	C8H6F3NO2
Molecular Weight	211.13 g/mol
Synonyms	(R)-2-Amino-2-(3,4,5-trifluorophenyl)acetic acid; (R)-3,4,5-Trifluorophenylglycine; D-3,4,5-Trifluorophenylglycine; (2R)-2-Azanyl-2-(3,4,5-trifluorophenyl)ethanoic acid; (R)-α-Amino-(3,4,5-trifluorophenyl)acetic acid; (R)-TFPG; 1213483-86-3; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our (2R)-2-Amino-2-(3,4,5-Trifluorophenyl)Acetic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.