Description

[4-((2S)Pyrrolidin-2-Yl)Phenoxy]Difluoromethane is a chiral, fluorinated organic building block of significant interest in advanced synthetic chemistry. Its core value lies in the strategic combination of a stereodefined pyrrolidine moiety and a difluoromethoxy group, enabling precise modulation of molecular properties. This compound is essential for researchers and developers in the pharmaceutical and agrochemical industries seeking to create novel active ingredients with enhanced metabolic stability, bioavailability, and target selectivity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of small molecule drugs, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the design of next-generation herbicides and pesticides, where the difluoromethoxy group can improve lipophilicity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or functional additive for specialty polymers with unique surface properties.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological mechanisms.

Basic Information

Product Name	[4-((2S)Pyrrolidin-2-Yl)Phenoxy]Difluoromethane
CAS No.	1213159-79-5
Molecular Formula	C11H13F2NO
Molecular Weight	213.22 g/mol
Synonyms	(2S)-2-[4-(Difluoromethoxy)phenyl]pyrrolidine; 4-[(2S)-Pyrrolidin-2-yl]phenoxy-difluoromethane; (S)-2-(4-(Difluoromethoxy)phenyl)pyrrolidine; 1213159-79-5; (S)-4-(Pyrrolidin-2-yl)phenoxy-difluoromethane; Difluoromethoxy-(4-[(2S)-pyrrolidin-2-yl]phenyl) ether
EINECS	Contact for details

Quality Control

Our production of [4-((2S)Pyrrolidin-2-Yl)Phenoxy]Difluoromethane adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized by advanced analytical techniques including HPLC, GC, and NMR to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.