Description

n-Boc-L-Phe(2-Ocf3)-Oh is a specialized, non-natural amino acid derivative featuring a trifluoromethoxy substituent on the phenyl ring and a tert-butyloxycarbonyl (Boc) protecting group. This compound is a critical building block in modern pharmaceutical research and development, enabling the synthesis of novel peptides and peptidomimetics with enhanced metabolic stability and binding affinity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the discovery and production of new therapeutic agents.

Application

• Pharmaceutical Intermediates: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Peptide Drug Discovery: Incorporation into peptide sequences to modulate their physicochemical properties, such as lipophilicity and conformational stability.
• Protease Inhibitor Development: Used in the design and synthesis of inhibitors for enzymes like proteases, where the fluorinated aromatic moiety can enhance target interaction.
• Chemical Biology Probes: Serves as a building block for creating labeled or modified peptides used in biochemical and cellular assays.
• Process Chemistry & Scale-up: Employed in the development of robust and scalable synthetic routes for advanced drug candidates during clinical manufacturing.
• Academic Research: Utilized in university and institutional labs for studying peptide structure-activity relationships and developing new synthetic methodologies.

Basic Information

Product Name	n-Boc-L-Phe(2-Ocf3)-Oh
CAS No.	1213060-08-2
Molecular Formula	C15H18F3NO5
Molecular Weight	349.30 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-[2-(trifluoromethoxy)phenyl]propanoic acid; Boc-L-2-(Trifluoromethoxy)phenylalanine; N-Boc-O-(2-trifluoromethyl)-L-phenylalanine; tert-Butyl (2S)-2-amino-3-[2-(trifluoromethoxy)phenyl]propanoate; Boc-Phe(2-OCF3)-OH; BOC-L-PHE(2-OCF3)-OH; N-(tert-Butoxycarbonyl)-2-(trifluoromethoxy)-L-phenylalanine
EINECS	Contact for details

Quality Control

Our n-Boc-L-Phe(2-Ocf3)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity, and identity confirmation. We adhere to industry best practices, and specifications can be aligned with customer requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.