Description

3,3',5'-Triiodo-L-Thyronine-13C6 is a stable isotope-labeled analog of the thyroid hormone triiodothyronine (T3), where six carbon atoms are replaced with the 13C isotope. This compound is a critical tool for precise quantitative analysis in biomedical research and pharmaceutical development, enabling accurate measurement of T3 levels and metabolism through advanced techniques like LC-MS/MS. It is essential for researchers and laboratories in endocrinology, pharmacology, and clinical diagnostics who require the highest standards of accuracy and traceability in their analytical methods.

Application

• Internal Standard for Mass Spectrometry: Serves as a primary internal standard for the precise quantification of endogenous triiodothyronine (T3) in biological matrices (e.g., serum, plasma, tissue) using LC-MS/MS.
• Metabolic Pathway Tracing: Used in isotope dilution studies to investigate the metabolic fate, turnover rates, and pharmacokinetics of thyroid hormones in vivo.
• Clinical Diagnostics Development: A key reference material in the development and validation of high-sensitivity clinical assays for thyroid function testing.
• Pharmaceutical R&D: Employed in drug discovery and development programs targeting thyroid hormone receptors or metabolic pathways.
• Quality Control & Method Validation: Critical for ensuring accuracy, precision, and compliance in regulated bioanalytical laboratories (GLP/GCP environments).

Basic Information

Product Name	3,3',5'-Triiodo-L-Thyronine-13C6
CAS No.	1213055-23-2
Molecular Formula	C913C6H11I3N1O4
Molecular Weight	~657.0 g/mol (for 13C6 labeled form)
Synonyms	Liothyronine-13C6; T3-13C6; L-Triiodothyronine-13C6; 3,3',5-Triiodo-L-thyronine-13C6; (S)-2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid-13C6; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine-13C6; Cytomel-13C6; Tertroxin-13C6
EINECS	Contact for details

Quality Control

Every batch of 3,3',5'-Triiodo-L-Thyronine-13C6 is manufactured and analyzed under strict quality systems to ensure identity, purity, and isotopic enrichment meet the exacting requirements for use as an analytical standard. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data on isotopic purity, chemical purity (by HPLC), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.