Description

(2R)-2-Amino-2-[2-Fluoro-5-(Trifluoromethyl)Phenyl]Ethan-1-Ol is a chiral amino alcohol building block of significant interest in advanced organic synthesis. This compound matters because its unique trifluoromethyl and fluoro-substituted aromatic core imparts desirable physicochemical properties, making it a critical intermediate for high-value applications. Pharmaceutical research and development teams, particularly those working on novel active pharmaceutical ingredients (APIs) and agrochemicals, need this high-purity chiral synthon to accelerate their discovery and process chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine and trifluoromethyl groups enhance biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Incorporated into specialty polymers and advanced organic materials to modify thermal and chemical resistance properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	(2R)-2-Amino-2-[2-Fluoro-5-(Trifluoromethyl)Phenyl]Ethan-1-Ol
CAS No.	1213032-20-2
Molecular Formula	C9H9F4NO
Molecular Weight	223.17 g/mol
Synonyms	(R)-2-Amino-2-(2-fluoro-5-(trifluoromethyl)phenyl)ethanol; (2R)-2-Amino-2-(2-fluoro-α,α,α-trifluoro-p-tolyl)ethanol; 2-Fluoro-5-(trifluoromethyl)benzene glycidol amine; (R)-1-(2-Fluoro-5-(trifluoromethyl)phenyl)-2-aminoethanol; Amino alcohol intermediate 1213032-20-2; (R)-ATFE; (2R)-ATFPE
EINECS	Contact for details

Quality Control

Our (2R)-2-Amino-2-[2-Fluoro-5-(Trifluoromethyl)Phenyl]Ethan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.