Description

(R)-2-(Amino(Cyclopropyl)Methyl)Benzonitrile Hydrochloride CAS NO 1213004-19-3 is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic value. Its core value lies in providing a stereochemically defined, functionalized benzonitrile scaffold essential for constructing complex bioactive molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, antiviral agents, and other therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile building block for constructing compound libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Asymmetric Synthesis: Serves as a precursor for the preparation of more complex chiral amines and amino acid derivatives via further chemical transformations.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable manufacturing of candidate drugs.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying enzyme function or biological pathways.

Basic Information

Product Name	(R)-2-(Amino(Cyclopropyl)Methyl)Benzonitrile Hydrochloride
CAS No.	1213004-19-3
Molecular Formula	C11H13N2•HCl
Molecular Weight	208.70 g/mol (Free base: 172.24 g/mol)
Synonyms	(R)-2-((Aminocyclopropyl)methyl)benzonitrile hydrochloride; (R)-2-(Amino(cyclopropyl)methyl)benzonitrile HCl; (1R)-2-(Aminomethyl)-2-cyclopropylbenzonitrile hydrochloride; Benzonitrile, 2-[(aminocyclopropyl)methyl]-, hydrochloride, (R)-; (R)-α-(Aminocyclopropyl)-o-tolunitrile hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-(Amino(Cyclopropyl)Methyl)Benzonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.