Description

(R)-3-(1-Aminobutyl)Benzonitrile Hydrochloride is a high-purity chiral intermediate featuring a benzonitrile core with a butylamine side chain. This compound matters as a critical building block in the synthesis of enantiomerically pure pharmaceuticals, where its specific stereochemistry is essential for biological activity and regulatory approval. It is primarily needed by research institutions and pharmaceutical manufacturers developing active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) agents and cardiovascular drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used in the construction of complex molecules requiring the (R)-enantiomer configuration for optimal efficacy.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target drug candidates.
• Reference Standard: Utilized as an analytical standard for method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	(R)-3-(1-Aminobutyl)Benzonitrile Hydrochloride
CAS No.	1212968-03-0
Molecular Formula	C11H15N2•HCl
Molecular Weight	210.71 g/mol (Free base: 175.25 g/mol)
Synonyms	(R)-3-(1-Aminobutyl)benzonitrile HCl; (R)-α-Butyl-3-cyanobenzylamine hydrochloride; (R)-3-(Aminomethyl)heptanenitrile hydrochloride; Benzonitrile, 3-[(1R)-1-aminobutyl]-, hydrochloride; (R)-3-(1-Amino-butyl)-benzonitril hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-(1-Aminobutyl)Benzonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.