Description

2-((1S)-1-Amino-2-Hydroxyethyl)Benzenecarbonitrile is a chiral, high-purity organic intermediate featuring both amino and hydroxy functional groups on a benzonitrile scaffold. This compound is of significant value for its role as a key building block in the synthesis of complex, biologically active molecules. It is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of novel therapeutic agents, particularly in areas requiring stereochemical control.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and production of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and cardiovascular drugs.
• Asymmetric Synthesis: Serves as a versatile precursor in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Ligand and Catalyst Development: Used in the design and synthesis of novel chiral ligands and organocatalysts for use in stereoselective transformations.
• Peptidomimetic Research: The amino alcohol moiety makes it valuable for creating non-peptide scaffolds that mimic peptide structures in drug discovery.
• Agrochemical Synthesis: Employed in the development of advanced, chiral agrochemicals such as herbicides and fungicides.
• Material Science Precursor: Potential use in synthesizing specialized polymers and functional materials with specific optical or chemical properties.

Basic Information

Item	Details
Product Name	2-((1S)-1-Amino-2-Hydroxyethyl)Benzenecarbonitrile
CAS No.	1212867-42-9
Molecular Formula	C9H10N2O
Molecular Weight	162.19 g/mol
Synonyms	(S)-2-Amino-2-(2-cyanophenyl)ethanol; (1S)-1-Amino-2-(2-cyanophenyl)ethanol; (S)-2-(2-Cyanophenyl)glycinol; Benzenecarbonitrile, 2-[(1S)-1-amino-2-hydroxyethyl]-; L-2-Amino-2-(2-cyanophenyl)ethanol; (S)-α-(Aminomethyl)-2-cyanobenzyl alcohol
EINECS	Contact for details

Quality Control

Our 2-((1S)-1-Amino-2-Hydroxyethyl)Benzenecarbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess (typically >99% ee), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.