Description

trans-1-(Boc-Amino)-3-(Bromomethyl)Cyclohexane, 97% is a high-purity, protected amino acid derivative and versatile bifunctional building block essential for advanced organic synthesis. Its molecular structure, featuring both a tert-butoxycarbonyl (Boc)-protected amine and a reactive bromomethyl group, makes it a critical intermediate for constructing complex molecules with precise stereochemistry. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as peptide mimetics, linker chemistry, and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in creating constrained peptide analogs and bioactive molecules with cyclohexane scaffolds.
• Peptidomimetic Chemistry: Used to introduce rigid, non-natural amino acid residues into peptide chains to enhance metabolic stability and binding affinity.
• Linker and Spacer Synthesis: The reactive bromomethyl group enables its use in constructing chemical linkers for bioconjugation, prodrug strategies, and solid-phase synthesis.
• Agrochemical Research: Serves as an intermediate in the development of new herbicides, fungicides, and plant growth regulators with tailored properties.
• Material Science Precursor: Can be utilized in the synthesis of functionalized monomers for specialty polymers and advanced materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and pathways.

Basic Information

Product Name	trans-1-(Boc-Amino)-3-(Bromomethyl)Cyclohexane, 97%
CAS No.	1212405-03-2
Molecular Formula	C₁₂H₂₂BrNO₂
Molecular Weight	292.21 g/mol
Synonyms	trans-1-[(tert-Butoxycarbonyl)amino]-3-(bromomethyl)cyclohexane; 1-N-Boc-3-(bromomethyl)cyclohexanamine (trans); trans-3-(Bromomethyl)-1-((tert-butoxycarbonyl)amino)cyclohexane; trans-N-Boc-3-(bromomethyl)cyclohexylamine; (1R,3R)-1-((tert-Butoxycarbonyl)amino)-3-(bromomethyl)cyclohexane; (1S,3S)-1-((tert-Butoxycarbonyl)amino)-3-(bromomethyl)cyclohexane; Boc-3-(bromomethyl)cyclohexylamine (trans); tert-Butyl (trans-3-(bromomethyl)cyclohexyl)carbamate
EINECS	Contact for details

Quality Control

Our trans-1-(Boc-Amino)-3-(Bromomethyl)Cyclohexane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical development, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.