Description

trans-1-(Boc-Amino)-3-(n-Methoxy-n-Methylcarbamoyl)Cyclohexane, 97% is a high-purity, protected amino acid derivative featuring both a Boc-protected amine and a Weinreb amide functional group. This compound is a critical advanced pharmaceutical intermediate (API intermediate) designed for the controlled synthesis of complex molecules. It is primarily utilized by research organizations and pharmaceutical manufacturers engaged in drug discovery and process development, particularly for peptide mimetics and small molecule therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetic Synthesis: Used to construct constrained, non-natural amino acid scaffolds that mimic peptide structures for enhanced metabolic stability.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs due to its versatile reactive handles.
• Weinreb Amide Applications: The n-Methoxy-n-Methylcarbamoyl (Weinreb amide) group allows for controlled nucleophilic addition to yield ketones or aldehydes, preventing over-addition.
• Boc-Protected Amine Utility: The tert-butoxycarbonyl (Boc) protecting group provides orthogonal protection for the amine functionality, which can be cleanly deprotected under mild acidic conditions.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	trans-1-(Boc-Amino)-3-(n-Methoxy-n-Methylcarbamoyl)Cyclohexane, 97%
CAS No.	1212331-06-0
Molecular Formula	C15H28N2O4
Molecular Weight	300.40 g/mol
Synonyms	trans-1-((tert-Butoxycarbonyl)amino)-3-(methoxy(methyl)carbamoyl)cyclohexane; 1-[(tert-Butoxycarbonyl)amino]-3-[(methoxy(methyl)amino)carbonyl]cyclohexane (trans); trans-1-(Boc-amino)-3-(N-methoxy-N-methylcarbamoyl)cyclohexane; Boc-trans-3-(Weinreb amide)cyclohexylamine; trans-1-Amino-3-(N-methoxy-N-methylcarboxamido)cyclohexane 1-Boc derivative; Cyclohexanecarboxamide, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[methoxy(methyl)amino]carbonyl]-, trans-; N-Boc-trans-3-(N-Methoxy-N-methylcarbamoyl)cyclohexylamine
EINECS	Contact for details

Quality Control

Our trans-1-(Boc-Amino)-3-(n-Methoxy-n-Methylcarbamoyl)Cyclohexane, 97% is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Quality is verified against established in-house specifications using advanced techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.