Description

trans-2-Benzyloxycarbonylaminocyclobutanecarboxylic Acid CAS NO 1212272-03-1 is a high-purity, protected cyclobutane amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, four-membered ring scaffold for constructing novel molecular architectures with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for applications in peptide mimetics, medicinal chemistry, and the synthesis of constrained bioactive molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel drug candidates, especially protease inhibitors and GPCR-targeted therapies.
• Peptidomimetics & Conformationally Restricted Peptides: Used to introduce cyclobutane constraints into peptide backbones to enhance metabolic stability, potency, and selectivity.
• Medicinal Chemistry & SAR Studies: A versatile building block for structure-activity relationship (SAR) exploration due to its defined stereochemistry and rigid ring structure.
• Agrochemical Research: Intermediate in the synthesis of novel herbicides, fungicides, or insecticides with unique modes of action.
• Chemical Biology Probes: Incorporation into activity-based probes or photoaffinity labels for studying enzyme function and protein-protein interactions.
• Academic & Contract Research: Serves as a specialized reagent for methodological development in asymmetric synthesis and ring chemistry.

Basic Information

Product Name	trans-2-Benzyloxycarbonylaminocyclobutanecarboxylic Acid
CAS No.	1212272-03-1
Molecular Formula	C13H15NO4
Molecular Weight	249.26 g/mol
Synonyms	(1R,2S)-2-[[(Benzyloxy)carbonyl]amino]cyclobutanecarboxylic Acid; (1R,2S)-2-(Cbz-amino)cyclobutanecarboxylic Acid; trans-2-(N-Cbz-amino)cyclobutanecarboxylic Acid; trans-2-[(Benzyloxycarbonyl)amino]cyclobutanecarboxylic Acid; Cbz-(1R,2S)-ACBC-OH; Z-(1R,2S)-ACBC-OH; Cyclobutane amino acid derivative; 2-[[(Phenylmethoxy)carbonyl]amino]cyclobutanecarboxylic acid (trans-)
EINECS	Contact for details

Quality Control

Our trans-2-Benzyloxycarbonylaminocyclobutanecarboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by advanced analytical techniques, including HPLC, NMR, and chiral analysis, to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers' development and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.